Pyrroloquinoline quinone disodium salt

Dosage: 10 mg

PQQ is one of the only known compounds that can stimulate the growth of entirely new mitochondria in your cells through a process called mitochondrial biogenesis. While most supplements support existing function, PQQ literally builds new cellular power plants.

The Mitochondrial Decline: Research shows mitochondrial density drops dramatically with age—from ~2,000 per cell at age 25 to ~200 by age 70. PQQ can increase mitochondrial number by 20-30% within weeks, effectively reversing cellular aging at the energy level.

Why Supplementation is Essential: Though found in human breast milk, dietary PQQ intake averages less than 1mcg daily from foods. You'd need pounds of fermented soybeans to approach THRIVE's therapeutic 10mg dose.

Cellular Benefits:

• Activates PGC-1α gene for new mitochondrial growth
• Enhanced brain cell energy metabolism and cognitive support
• Improved cardiac mitochondrial function and energy efficiency
• Supports healthy cellular aging and energy production

Synergistic Formulation: Works with CoQ10 (also in THRIVE) for comprehensive mitochondrial support—PQQ grows new mitochondria while CoQ10 optimizes their function.†

→Learn more about how PQQ can grow new mitochondria

Relevant studies

Chowanadisai et al. Journal of Biological Chemistry. 2010
Anthony. Antioxidants & Redox Signaling. 2001
Paz. Journal of Biological Chemistry. 1991

Ubiquinone

Dosage: 200 mg

CoQ10 is the cellular spark plug essential for mitochondrial energy production. Without adequate CoQ10, your mitochondria cannot complete the electron transport chain that converts food into usable cellular energy (ATP).

The Age-Related Problem: Your body's CoQ10 production declines by ~50% between age 25 and 50, directly contributing to energy decline and cardiovascular risk. Most people operate with severely compromised cellular energy systems without realizing it.

Therapeutic Dosing: While basic multivitamins provide 10-30mg (if any), research shows 100-300mg is required for meaningful mitochondrial support. THRIVE's 200mg targets the therapeutic range for cellular energy restoration.

Enhanced Absorption: THRIVE includes 10mg Bioperine to significantly enhance CoQ10 uptake, ensuring your cells actually receive this critical compound.

Cellular Benefits:

• Essential cofactor for ATP production in every cell
• Heart muscle support (highest CoQ10 requirements)
• Mitochondrial membrane protection from oxidative damage
• Supports healthy cellular aging

Synergistic Formulation: Works with PQQ (also in THRIVE) for comprehensive mitochondrial support—PQQ grows new mitochondria while CoQ10 optimizes existing function.†

→Learn more about the benefits of CoQ10 for energy and heart health

Relevant studies

Saini. Journal of Pharmacy and Bioallied Sciences. 2011
Hernández-Camacho et al. Frontiers in Physiology. 2018
Barcelos et al. Biology. 2019
Fukuda et al. Biofactors. 2016
Zhang et al. Food and Function. 2018
Fan et al. Pharmacological Research. 2017
Mine et al. Journal of Clinical Biochemistry and Nutrition. 2022
Stout et al. Biology (Basel). 2019
Zmitek et al. Biofactors. 2017

Methylated B vitamins

Dosages:

B1 (benfotiamine) — 100 mg
B2 (riboflavin 5-phosphate) — 15 mg
B3 (niacinamide) — 50 mg
B5 (calcium pantothenate) — 50 mg
B6 (pyrodoxal 5-phosphate) — 25 mg
B7 (biotin) — 1 mg
B9 (methylfolate) — 500 mcg
B12 (methylcobalamin) — 500 mcg

B vitamins are essential cofactors for cellular energy production, neurotransmitter synthesis, and methylation pathways. THRIVE uses active forms like methylcobalamin (B12) and methylfolate (B9) that your body can immediately utilize without conversion.

The Form Problem: Most supplements use cheap synthetic forms like cyanocobalamin (B12) and folic acid (B9). Up to 40% of people have genetic variations (like MTHFR mutations) that make it difficult to convert these synthetic forms, leaving them functionally deficient despite supplementation.

Therapeutic Approach: While basic multivitamins provide RDA amounts designed to prevent deficiency, cellular energy production under stress requires 5-10x higher doses. THRIVE provides therapeutic levels of active B vitamins for optimal mitochondrial function.

Cellular Benefits:

• Essential cofactors for mitochondrial ATP production
• Neurotransmitter synthesis for mood and cognitive function
• Methylation support for cellular repair and detoxification
• Nervous system maintenance and cardiovascular protection
• Hormone production and stress response optimization

Why Active Forms Matter: Methylcobalamin and methylfolate bypass genetic conversion limitations, ensuring reliable cellular utilization regardless of individual biochemistry.†

→Learn more about the signs of B12 deficiency

→Learn why methylfolate is the only form you should take

Relevant studies

Kennedy. Nutrients. 2016
Hanna et al. The Permanente Journal. 2022
Young et al. Nutrients. 2019
Peterson et al. Nutrients. 2020
Ford et al. Nutrients. 2018
Calderón-Ospina et al. CNS Neuroscience and Therapeutics. 2020
Calvaresi et al. The journals of gerontology Series B, Psychological sciences and social sciences. 2001

Magnesium glycinate

Dosage: 400 mg

Magnesium is required for over 300 enzymatic reactions, including every step of ATP production in your mitochondria. Despite its critical importance, up to 80% of people are magnesium deficient due to soil depletion and modern stress.

The Form Advantage: Most supplements use magnesium oxide with only 4% absorption. THRIVE uses magnesium glycinate with 80% absorption—a 20x difference in bioavailability. This chelated form reaches your cells where magnesium is actually needed.

The Deficiency Crisis: Modern agriculture has depleted soil magnesium by 80% since 1950. Add chronic stress (which depletes magnesium), processed foods (which lack magnesium), and medications (which block absorption), and widespread deficiency becomes inevitable.

Therapeutic Dosing: While basic multivitamins provide 50-100mg of poorly absorbed magnesium, cellular function requires 400-600mg daily. THRIVE's 400mg of highly bioavailable magnesium glycinate targets optimal cellular support.

Cellular Benefits:

• Essential cofactor for mitochondrial ATP synthesis
• Nervous system regulation and stress response optimization
• Muscle and cardiovascular function support
• Sleep quality enhancement through neurotransmitter regulation
• Blood sugar metabolism and insulin sensitivity

Critical for Energy: Without adequate magnesium, your mitochondria cannot efficiently produce ATP, leading to cellular energy deficits that manifest as fatigue, anxiety, and poor recovery.†

→Learn more about magnesium deficiency symptoms

Relevant studies:

Grober et al. Nutrients. 2015
Bailey et al. American Journal of Clinical Nutrition. 2011
Noah et al. Magnesium Research. 2020
Barragan-Rodriguez et al. Magnes Res. 2008
Mah et al. BMC Complementary Medicine and Therapies. 2021
Zhang et al. Nutrients. 2017

Taurine

Dosage: 400 mg

Taurine is a semi-essential amino acid concentrated in your most energy-demanding tissues—heart, brain, and skeletal muscle. It's critical for mitochondrial membrane stability and cellular energy efficiency, yet your body's production declines significantly with age.

The Age-Related Decline: Taurine levels drop by approximately 50% between age 25 and 65. This decline directly correlates with reduced mitochondrial function, cardiovascular capacity, and neurological performance—explaining why taurine supplementation shows remarkable anti-aging effects.

Cellular Protection Mechanisms: Taurine stabilizes mitochondrial membranes and regulates cellular calcium handling, preventing the calcium overload that damages cellular energy systems. It also functions as a powerful antioxidant, protecting mitochondria from oxidative stress.

Why Food Sources Fall Short: While found in animal products, modern diets provide insufficient taurine for optimal cellular function. Therapeutic benefits require 400-1000mg daily—far beyond typical dietary intake.

Cellular Benefits:

• Mitochondrial membrane stabilization and protection
• Cardiac muscle energy efficiency and rhythm regulation
• Neurological function and cognitive performance support
• Cellular antioxidant defense and longevity promotion
• Electrolyte balance and muscle function optimization

Longevity Connection: Research shows taurine supplementation can extend lifespan and improve multiple markers of healthy aging through enhanced mitochondrial function and cellular protection.†

→Learn more about the benefits of taurine for your brain and heart

Relevant studies

Ripps et al. Molecular Vision. 2012
Marcinkiewicz. Amino Acids. 2014
Schaffer et al. Canadian Journal of Physiology and Pharmacology. 2009
Militante et al. Amino Acids. 2002
Allard et al. Heart Failure Reviews. 2006
Redmond et al. Nutrition. 1998

Rhodiola rosea extract (standardized to 3% rosavin / 2% salidroside)

Dosage: 200 mg

Rhodiola rosea is a powerful adaptogenic herb that enhances cellular energy efficiency under stress while supporting mitochondrial resilience. Its primary bioactive compound, salidroside, specifically protects brain cells from stress-induced energy depletion.

Cellular Adaptation Mechanisms: Rhodiola works at the cellular level to improve energy utilization during physical and mental stress. It enhances mitochondrial efficiency, allowing cells to maintain optimal function even under challenging conditions.

Stress-Energy Connection: Unlike stimulants that force energy output, rhodiola optimizes how your cells use available energy. This results in sustained performance without the crash associated with artificial energy boosters.

Bioactive Standardization: THRIVE's rhodiola is standardized for salidroside content—the compound most responsible for cognitive and stress-protective effects. Many rhodiola supplements lack proper standardization, providing inconsistent benefits.

Cellular Benefits:

• Enhanced mitochondrial efficiency under stress conditions
• Cognitive function protection during mental fatigue
• Physical endurance optimization through improved cellular energy utilization
• Immune system resilience and stress response modulation
• Neurological protection from oxidative stress

Synergistic Formulation: Works synergistically with KSM-66 (also in THRIVE) for comprehensive stress adaptation—rhodiola optimizes energy utilization while KSM-66 reduces cortisol's damaging effects on mitochondria.†

→Learn about the benefits of rhodiola for energy, fatigue, and mental performance

Relevant studies

Panossian et al. Phytomedicine. 2010
Zhong et al. Drug Design, Development and Therapy. 2018
Panossian et al. Pharmaceuticals. 2010

Potassium iodide

Dosage: 200 mcg

Iodine is essential for thyroid hormone synthesis, which directly controls mitochondrial biogenesis and cellular energy metabolism. Despite being critical for cellular function, iodine deficiency has become increasingly common due to reduced salt intake and soil depletion.

The Thyroid-Mitochondria Connection: Thyroid hormones T3 and T4 regulate the genes controlling mitochondrial biogenesis—literally determining how many cellular power plants your body produces. Without adequate iodine, thyroid function suffers, leading to reduced mitochondrial density and cellular energy deficits.

The Modern Deficiency Problem: Iodized salt consumption has declined while processed foods (using non-iodized salt) have increased. Additionally, environmental toxins like bromide and fluoride compete with iodine, increasing requirements beyond typical dietary intake.

Cellular Energy Regulation: Thyroid hormones control your metabolic rate at the cellular level, determining how efficiently mitochondria produce energy. Even mild thyroid dysfunction from iodine deficiency can significantly impact energy levels and cognitive function.

Cellular Benefits:

• Essential for thyroid hormone synthesis and mitochondrial biogenesis regulation
• Cellular metabolism and energy production optimization
• Brain function and cognitive performance support through neural energy metabolism
• Metabolic rate regulation and hormonal balance
• Cellular detoxification and halogen displacement

Optimal Form: Potassium iodide provides bioavailable iodine for reliable thyroid function, ensuring consistent cellular energy regulation regardless of dietary iodine variability.†

→Learn why you're not getting enough iodine

Relevant studies

Hermann et al. Journal of Psychiatry and Neuroscience. 2004
Zimmermann et al. The Lancet Diabetes and Endocrinology. 2015
Di Liegro. Molecular Medicine Reports. 2008
Zava et al. Thyroid Research. 2011
Niwattisaiwong et al. Cleveland Clinic Journal of Medicine. 2017

Quercetin phytosome

Dosage: 250 mg

Quercetin is a powerful flavonoid that protects mitochondria from inflammatory damage while supporting cellular cleanup mechanisms. It's one of the most researched compounds for healthy aging, but standard quercetin has extremely poor absorption.

The Absorption Solution: THRIVE uses Quercefit Quercetin Phytosome™, which increases plasma levels up to 20x compared to standard quercetin. This advanced delivery system ensures therapeutic levels reach your cells where quercetin can function effectively.

Cellular Protection Mechanisms: Quercetin protects mitochondrial membranes from inflammatory damage while supporting your body's natural cellular cleanup processes, including the removal of damaged senescent cells that accumulate with age and contribute to inflamm-aging.

Beyond Basic Antioxidants: Unlike simple antioxidants, quercetin has specific anti-inflammatory mechanisms and helps boost glutathione production—your body's master antioxidant system for cellular protection.

Cellular Benefits:

• Mitochondrial membrane protection from inflammatory damage
• Cellular cleanup and healthy aging support
• Enhanced glutathione production for detoxification
• Immune system modulation and inflammatory response optimization
• Longevity pathway support through inflamm-aging reduction

Why Enhanced Absorption Matters: Without proper delivery technology, most quercetin supplements provide minimal cellular benefit. The Phytosome™ form ensures meaningful anti-aging effects.†

→Learn more about the benefits of quercetin for inflammation, immunity, and cellular protection

Relevant studies

Deepika & Maurya. Molecules. 2022
Kashyap et al. Biomolecules. 2019
Gökbilen et al. Nutrition Research. 2022

Ascorbic acid

Dosage: 500 mg

Vitamin C is a foundational antioxidant that supports mitochondrial function, neurotransmitter synthesis, and cellular repair mechanisms. Unlike most animals, humans cannot produce vitamin C and must obtain therapeutic amounts through supplementation.

The Therapeutic Dose Difference: While the RDA of 90mg prevents scurvy, research shows 500-1000mg daily is required for optimal cellular protection, immune function, and mitochondrial support. Basic multivitamins rarely provide therapeutic amounts.

Cellular Energy Support: Vitamin C is essential for L-carnitine synthesis—a compound that transports fatty acids into mitochondria for energy production. It also protects mitochondrial membranes from oxidative damage during energy generation.

Neurotransmitter Production: Vitamin C is a required cofactor for dopamine synthesis, directly impacting mood, focus, and motivation. Adequate levels support optimal brain function and stress resilience.

Cellular Benefits:

• Mitochondrial protection during energy production
• L-carnitine synthesis for fatty acid metabolism
• Dopamine and neurotransmitter production support
• Collagen synthesis for tissue repair and maintenance
• Immune cell function and inflammatory response modulation
• Cellular antioxidant regeneration (recycles vitamin E and glutathione)

Water-Soluble Advantage: As a water-soluble vitamin, excess vitamin C is safely excreted, making higher therapeutic doses well-tolerated while ensuring consistent cellular protection.†

Relevant studies:

Alessio et al. International Journal of Sports Nutrition and Exercise Metabolism. 1997
Huijskens et al. Journal of Leukocyte Biology. 2014
Paleologos et al. American Journal of Epidemiology. 1998
Padayatty et al. Oral Diseases. 2016
Boyera et al. International Journal of Cosmetic Science. 1998
Amr et al. Nutrition Journal. 2013
Duarte et al. Free Radical Biology and Medicine. 2009
Aguirre et al. Pharmacology and Therapeutics. 2008
Hansen et al. Nutrients. 2014

Cholecalciferol

Dosage: 4,000 IU

Vitamin D functions as a steroid hormone that regulates over 1,000 genes, including those controlling mitochondrial biogenesis, immune function, and cellular energy metabolism. Despite its critical importance, up to 75% of people are deficient.

The Deficiency Crisis: Modern indoor lifestyles and sun avoidance have created widespread vitamin D deficiency. Blood levels below 30 ng/mL (considered deficient) are linked to increased risk of autoimmune diseases, mood disorders, and reduced mitochondrial function.

Why 4,000 IU Matters: The RDA of 600 IU prevents rickets but is inadequate for optimal cellular function. Research shows most people require at least 4,000 IU daily to achieve blood levels of 50-80 ng/mL associated with optimal health outcomes.

Cellular Energy Connection: Vitamin D regulates mitochondrial calcium handling and influences genes controlling mitochondrial biogenesis. Deficiency directly impairs cellular energy production and metabolic function.

Cellular Benefits:

• Mitochondrial biogenesis and energy metabolism regulation
• Immune cell function and inflammatory response modulation
• Calcium absorption and bone mineralization support
• Sex hormone production (testosterone, estrogen) optimization
• Mood regulation through neurotransmitter pathways
• Cellular differentiation and gene expression control

Critical Pairing: Vitamin D increases calcium absorption, making vitamin K2 (also in THRIVE) essential to direct calcium to bones rather than arteries—a synergistic combination for optimal health.†

→Learn how to spot the signs of vitamin D deficiency

Relevant studies:

Holick. Reviews in Endocrine and Metabolic Disorders. 2017
Barke et al. Current Opinion in Pharmacology. 2010
Cheng et al. Depression and Anxiety. 2020
Nowak et al. Medicine (Baltimore). 2016
Ginde et al. Archives of Internal Medicine. 2009
Holick et al. American Journal of Clinical Nurtition. 2008
Zittermann et al. Advances in Experimental Medicine and Biology. 2014
Evatt. Sleep. 2015
Harms et al. Best Practice & Research Clinical Endocrinology & Metabolism. 2011
Kechichian et al. American Journal of Clinical Dermatology. 2018
Fawzi et al. Journal of Cosmetic Dermatology. 2016

Menaquinone-4 & Menaquinone-7

Dosage: 1,000 mcg (MK-4) + 100 mcg (MK-7)

Vitamin K2 is a powerful hormone-like vitamin that regulates gene expression, mitochondrial function, and cellular energy metabolism. Far beyond basic vitamin functions, K2 acts as a master regulator of cellular growth, energy production, and tissue-specific protein activation.

Cellular Health Properties: K2 enhances mitochondrial electron transport efficiency and protects cellular membranes from oxidative damage. It regulates genes involved in cellular energy metabolism, inflammatory response, and aging processes—acting as a master switch for cellular optimization.

Anti-Cancer Protection: Research shows K2 induces apoptosis in cancer cells while protecting healthy cells. It regulates cell cycle progression and prevents the cellular mutations that lead to malignancy, with particularly strong effects against prostate and liver cancers.

MK-4 vs. MK-7 Functions: MK-4 is rapidly taken up by the brain, heart, kidneys, and reproductive organs where it supports cellular energy production and hormone synthesis. MK-7 activates Matrix Gla Protein and osteocalcin—proteins that control calcium placement and prevent arterial calcification.

Cellular Benefits:

• Mitochondrial efficiency and energy production optimization
• Anti-cancer gene expression and tumor suppression
• Vital organ cellular protection and function support
• Cellular aging prevention and DNA integrity maintenance

Synergistic Formulation: Works with vitamin D3 (also in THRIVE) to ensure proper calcium utilization—D3 enhances calcium absorption while K2 directs calcium to bones rather than arteries and soft tissues.†

→Learn why vitamin K2 deficiency is tide to chronic disease

Relevant studies:

Grober et al. Dermato-Endocrinology. 2015
Theuwissen et al. Advances in Nutrition. 2012
Cockayne et al. Archives of Internal Medicine. 2006
Geleijnse et al. Journal of Nutrition. 2004
Shea et al. American Journal of Epidemiology. 2008
Ferland. Advances in Nutrition. 2012

KSM-66 ashwagandha root extract

Dosage: 200 mg

KSM-66 is the most clinically studied ashwagandha extract, standardized to preserve the natural ratios of bioactive compounds found in the root. This adaptogenic herb helps protect mitochondria from stress-induced damage while optimizing cellular energy under pressure.

The Stress-Mitochondria Connection: Chronic stress elevates cortisol, which directly damages mitochondrial membranes and impairs cellular energy production. KSM-66 helps regulate the HPA axis, reducing cortisol's destructive effects on cellular energy systems.

Why KSM-66 Specifically: Unlike generic ashwagandha extracts, KSM-66 uses a proprietary milk extraction process that preserves the full spectrum of withanolides while eliminating potentially toxic compounds like withaferin A found in leaf extracts.

Clinical Research: Studies with KSM-66 specifically show up to 30% cortisol reduction, improved stress resilience, enhanced cognitive function, and better physical performance—all markers of improved cellular energy utilization.

Cellular Benefits:

• HPA axis regulation and cortisol optimization for mitochondrial protection
• Cellular stress adaptation and energy efficiency under pressure
• Cognitive function and mental clarity enhancement
• Physical endurance and recovery optimization through cellular resilience
• Sleep quality improvement via stress hormone regulation

Extract Quality: KSM-66's rigorous standardization ensures consistent bioactive levels, unlike generic ashwagandha powders with unpredictable potency and potential contaminants.†

→Learn more about the benefits of KSM-66 for stress, cortisol, and hormone balance

Relevant studies:

Lopresti et al. Medicine. 2019
Salve et al. Cureus Journal of Medical Science. 2019
Kelgane et al. Cureus Journal of Medical Science. 2020
Bonilla et al. Journal of Functional Morphology and Kinesiology. 2021
Ng et al. Phytotherapy Research. 2020
Chandrasekhar et al. Indian Journal of Psychological Medicine. 2012

L-selenomethionine

Dosage: 100 mcg

Selenium is an essential trace mineral that forms the active site of glutathione peroxidase—your body's most powerful cellular antioxidant enzyme. It's also critical for thyroid hormone activation, which directly controls mitochondrial biogenesis and energy metabolism.

The Soil Depletion Problem: Selenium content in foods depends entirely on soil levels, which vary dramatically by geography. Many regions have selenium-depleted soils, making dietary intake unreliable for optimal cellular protection.

Thyroid-Mitochondria Connection: Selenium is required to convert inactive T4 thyroid hormone to active T3, which directly regulates mitochondrial biogenesis and cellular energy production. Without adequate selenium, thyroid function—and cellular energy—suffers.

Cellular Antioxidant System: Selenium forms the core of glutathione peroxidase, which protects mitochondrial membranes from lipid peroxidation—one of the primary causes of mitochondrial damage and cellular aging.

Cellular Benefits:

• Glutathione peroxidase enzyme function for mitochondrial protection
• Thyroid hormone conversion for optimal metabolic rate
• Cellular antioxidant defense and membrane protection
• Immune system function and inflammatory response modulation
• DNA protection and cellular repair mechanisms

Optimal Dosing: 100mcg provides therapeutic levels for antioxidant enzyme function without approaching toxicity thresholds, ensuring reliable cellular protection regardless of dietary selenium intake.†

→Learn more about the signs of selenium deficiency

Relevant studies

Duntas. Hormone and Metabolic Research. 2009
Drutel et al. The Journal of Clinical Endocrinology and Metabolism. 2013
Huang et al. Antioxidants & Redox Signaling. 2012
Fang et al. Cancer Prevention Research. 2010

Zinc picolinate

Dosage: 20 mg

Zinc is an essential cofactor for over 300 enzymatic reactions, including those involved in cellular energy metabolism, DNA synthesis, and hormone production. Despite its critical importance, zinc deficiency is surprisingly common and difficult to detect through standard testing.

The Absorption Challenge: Most zinc supplements use zinc oxide or sulfate with poor bioavailability. THRIVE uses zinc picolinate, a chelated form with superior absorption that ensures cellular uptake where zinc is actually needed.

Cellular Energy Role: Zinc is required for key enzymes in cellular energy metabolism and mitochondrial function. It's also essential for the enzyme that converts testosterone precursors, directly linking zinc status to energy, mood, and hormonal health.

The Deficiency Problem: Zinc is lost through sweat, stress depletes zinc stores, and modern processed foods are zinc-poor. Even mild deficiency impairs immune function, cognitive performance, and cellular repair mechanisms.

Cellular Benefits:

• Essential cofactor for cellular energy metabolism enzymes
• DNA synthesis and cellular repair mechanisms
• Testosterone production and hormonal optimization
• Immune cell function and inflammatory response modulation
• Cognitive function and neurotransmitter synthesis support
• Cellular antioxidant enzyme (SOD) function

Balanced with Copper: THRIVE includes 2mg copper to maintain optimal zinc-to-copper ratios, preventing the mineral imbalances that can occur with isolated zinc supplementation.†

→Learn more about the warning signs of low zinc levels

Relevant studies

Prasad. Nutrition. 1995
Wessels et al. Nutrients. 2017
Klaus-Helge et al. Journal of Nutrition. 2003
Solati et al. Nutritional Neuroscience. 2015
Swardfager et al. Biological Psychiatry. 2013
Gupta et al. Dermatology Research and Practice. 2014

Copper glycinate

Dosage: 2 mg

Copper is an essential trace mineral required for mitochondrial energy production and neurotransmitter synthesis. It forms the active site of cytochrome c oxidase—a critical enzyme in the electron transport chain that generates cellular energy (ATP).

The Zinc-Copper Balance: High-dose zinc supplementation can deplete copper levels, creating dangerous imbalances. THRIVE includes 2mg of copper to maintain optimal ratios with its 20mg zinc dose, preventing the fatigue and neurological issues associated with copper deficiency.

Cellular Energy Role: Copper is essential for the final step of mitochondrial energy production. Without adequate copper, the electron transport chain cannot function efficiently, leading to reduced ATP synthesis and cellular energy deficits.

Neurotransmitter Synthesis: Copper is required for enzymes that synthesize dopamine and norepinephrine—neurotransmitters critical for mood, motivation, and cognitive function. Copper deficiency directly impairs mental clarity and emotional regulation.

Cellular Benefits:

• Essential cofactor for mitochondrial electron transport chain
• Dopamine and norepinephrine synthesis for mood and cognition
• Cellular antioxidant enzyme (SOD) function and oxidative protection
• Collagen synthesis and connective tissue health
• Male fertility support through healthy sperm production

Balanced Formulation: The 10:1 zinc-to-copper ratio in THRIVE prevents mineral competition while ensuring adequate copper for optimal mitochondrial and neurological function.†

Relevant studies

Olivares et al. American Journal of Clinical Nutrition. 1996
Tainer et al. Nature. 1983
Munoz et al. European Cytokine Network. 2005
Sajithlal et al. Molecular and Cellular Biochemistry. 1999
Prohaska. Advances in Nutrition. 2011

THRIVE focuses on cellular health optimization rather than just preventing deficiencies. We use premium, bioavailable forms (like magnesium glycinate, methylfolate, quercetin phytosome, etc.) at therapeutic doses that target specific cellular mechanisms: mitochondrial function, inflamm-aging, and stress adaptation. Basic multivitamins use cheap forms in minimal doses that your body largely can't absorb or use.†

Therapeutic doses of premium ingredients require space. A single capsule holds 750mg maximum. Our 400mg of magnesium glycinate alone nearly fills one capsule. We refuse to use fairy dust doses just to fit everything in fewer pills. Real cellular optimization requires meaningful amounts of each compound.†

Each ingredient is chosen to support specific cellular functions: PQQ stimulates new mitochondria growth, quercetin phytosome reduces cellular inflammation, KSM-66 optimizes cellular stress response. This isn't general "wellness" - it's targeting the fundamental mechanisms that drive energy, longevity, and optimal function.†

THRIVE replaces 12+ individual supplements with one expertly-formulated product. The ingredients are specifically chosen to work synergistically—vitamin D with K2 for calcium metabolism, magnesium for vitamin D activation, adaptogens that complement each other. You get better results with fewer pills at a lower cost.†

THRIVE is designed as a comprehensive cellular health foundation. Most people find they can reduce or eliminate other supplements because THRIVE addresses core cellular pathways. Always consult your healthcare provider about your specific supplement regimen, especially if taking medications.†

Many customers notice improved energy and sleep quality within 1-2 weeks as cellular energy production optimizes. More comprehensive benefits like stress resilience and inflammation reduction typically develop over 4-8 weeks as cellular health improves. Remember: we're optimizing fundamental biology, not providing quick fixes.†

Unlike stimulants or hormonal compounds, THRIVE's ingredients are designed for daily use. B-vitamins, minerals, and antioxidants need consistent replenishment. Adaptogens like ashwagandha and rhodiola work best with consistent use. No cycling required—just consistent cellular support.†

THRIVE has been formulated for adults over the age of 18. It is not suitable for children and should be kept out of their reach. Always consult your healthcare provider before taking any supplement.†

Each ingredient in THRIVE must pass a rigorous four-part test: 1) Multiple peer-reviewed human clinical studies demonstrating clear benefits, 2) Optimal bioavailability (form matters as much as dose), 3) Therapeutic dosage shown to produce measurable results, and 4) Synergistic effects with other ingredients. We reject dozens of potential ingredients that fail to meet all four criteria, even if they're trendy or marketable. Our formulation process prioritizes results you can actually feel, not marketing hype.†

We use premium forms your body actually recognizes: magnesium glycinate instead of oxide (80% vs 4% absorption), methylated B-vitamins instead of synthetic (no conversion required), quercetin phytosome instead of regular quercetin (20x better absorption). The form determines what your cells actually receive.†

At Stacks Vitamin Company, we stay at the forefront of scientific advancements to ensure THRIVE reflects the latest in evidence-based nutrition. This proactive approach allows us to assess and integrate new, high-quality ingredients into the THRIVE formula, ensuring it continues to meet our rigorous standards for excellence. Your well-being is our priority, and we are committed to evolving the THRIVE formula to reflect the most current and beneficial nutritional insights.†

We offer a 30-day money-back guarantee. If you're not completely satisfied, contact us for a full refund. We're confident THRIVE will make a difference, but we want you to try it risk-free.